What are miRNA inhibitors?
miRNA inhibitors are natural or artificial RNA transcripts that sequestrate miRNAs and decrease or even eliminate their depressing effects. Competing endogenous RNAs (ceRNAs) can be viewed as natural and endogenous miRNA inhibitors.
What is the function of microRNA miRNA?
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary miRNAs and processed into precursor miRNAs, and finally mature miRNAs.
How does miRNA inhibit gene expression?
microRNA controls gene expression mainly by binding with messenger RNA (mRNA) in the cell cytoplasm. Instead of being translated quickly into a protein, the marked mRNA will be either destroyed and its components recycled, or it will be preserved and translated later.
What is mimic microRNA?
The miRNA mimic technology (miR-Mimic) is an innovative approach for gene silencing. This approach is to generate nonnatural double-stranded miRNA-like RNA fragments.
What is the meaning of miRNA?
beloved
Mirna is a girl’s name meaning “beloved” that comes from the Irish and Gaelic name Myrna.
How do Antagomirs work?
AntagomiRs are synthetic 2-O-methyl RNA oligos of about 21–23 nucleotides which fully complement the miRNAs and effectively compete with miRNA target mRNAs with a stronger binding to the miRNA-associated gene silencing complexes (miRNA-RISCs).
mirVana miRNA inhibitors are chemically modified, single-stranded oligonucleotides with patented secondary structure designed to specifically bind to and inhibit endogenous miRNAs, resulting in up-regulation of target mRNA translation.
What are mirvana™ miRNAs?
miRNAs Go online to view related products. Product Description ∙ mirVana™ miRNA mimics are small, chemically modified, double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity. ∙ mirVana™ miRNA Mimics exhibit maximum and consistent effect in vitro at low concentration.
What is the mirvana miRNA mimic miR-1 positive control?
The mirVana miRNA Mimic miR-1 Positive Control (Cat. No. 4464062, 4462063, 4462064, 2262065) is designed to mimic mature miR-1 miRNA after delivery to mammalian cells. miR-1 is associated with down-regulation of many genes.
How are mirvana miRNA inhibitors delivered to the liver?
Results indicate that mirVana miRNA inhibitors were efficiently delivered to the liver with Invivofectamine 2.0, where they inactivated miR-122, leading to up-regulation of genes naturally suppressed by miR-122. In addition to our pre-defined miRNA libraries, mirVana mimics and inhibitors are available as custom collections.