Is trastuzumab generic?

Is trastuzumab generic?

Herceptin is the trade name for Trastuzumab. In some cases, health care professionals may use the trade name Herceptin when referring to the generic drug name Trastuzumab. Drug type: Herceptin is a monoclonal antibody. (For more detail, see “How this drug works” section below).

Is trastuzumab a chemotherapy?

Trastuzumab is used to treat metastatic (spread) breast cancer. It is effective against tumors that overexpress the HER2/neu protein. As part of chemotherapy regimen for adjuvant treatment of lymph-node positive, HER2/neu protein positive breast cancer. Treatment of gastric (stomach) cancer.

Is HER2 curable?

HER2-positive breast cancer is highly curable because of the availability of these HER2-targeted therapies, so we treat patients fairly aggressively upfront to reduce the risk of them experiencing a stage IV recurrence.

Is trastuzumab an immunotherapy?

The current mainstay of passive immunotherapy includes trastuzumab, pertuzumab, and trastuzumab emtansine (T-DM1).

What is trastuzumab made from?

The active substance trastuzumab is produced in recombinant Chinese Hamster Ovary cells using a serum free medium. The MCB, WCB and End of Production Cells were characterised sufficiently. MCB andWCB were adapted to growth in serum free medium.

How is trastuzumab given?

Trastuzumab is given through an infusion into vein (intravenous, IV). The first dose is given over 90 minutes. If well-tolerated subsequent maintenance doses may be given over 30 minutes.

How much does trastuzumab cost?

Trastuzumab costs $49,915 and $28,350 per patient treated in the adjuvant and metastatic breast cancer settings, respectively; bevacizumab costs $48,490 and $39,614 per patient treated in the metastatic lung and colorectal cancer settings, respectively.

How do you calculate dose of trastuzumab?

Determine the number in mg of Trastuzumab needed, based on a loading dose of 4 mg Trastuzumab/kg body weight or a maintenance dose of 2 mg Trastuzumab/kg body weight. Calculate the volume of 21 mg/mL Trastuzumab solution and withdraw this amount from the vial and add it to an infusion bag containing 250 mL of 0.9% Sodium Chloride Injection, USP.

What is the pH of trastuzumab?

Package Insert Herceptin (Trastuzumab) Genetech, Inc. Reconstitution with only 20 mL of the supplied Bacteriostatic Water for Injection (BWFI), USP, containing 1.1% benzyl alcohol as a preservative, yields a multi-dose solution containing 21 mg/mL Trastuzumab, at a pH of approximately 6.

What is the color of trastuzumab solution?

The solution should be essentially free of visible particulates, clear to slightly opalescent, and colorless to pale yellow. Determine the number in mg of Trastuzumab needed, based on a loading dose of 4 mg Trastuzumab/kg body weight or a maintenance dose of 2 mg Trastuzumab/kg body weight.