How does arsenic affect the digestive system?
Arsenic has shown the ability to perturb the gut microbe population leading to negative effects in mice and human. The ability of arsenic to increase pathogen-associated molecular patterns (PAMPs) in the perturbed gut can increase inflammatory response leading to adverse effects.
What are the effects of arsenic on the human body?
Breathing in high levels of arsenic can cause a sore throat and irritated lungs. Swallowing high levels of arsenic can cause nausea, vomiting, diarrhea, muscle weakness and cramping, skin rashes, and other problems. Exposure to high enough amounts of arsenic can be fatal.
What are the symptoms of too much arsenic?
The immediate symptoms of acute arsenic poisoning include vomiting, abdominal pain and diarrhoea. These are followed by numbness and tingling of the extremities, muscle cramping and death, in extreme cases.
Can arsenic cause stomach pain?
Clinical description. Acute ingestion of toxic amounts of inorganic arsenic typically causes severe gastrointestinal signs and symptoms (e.g., vomiting, abdominal pain, and diarrhea). These signs and symptoms might lead rapidly to dehydration and shock.
Does arsenic cause inflammation in body?
Arsenic exposure has been shown to cause inflammation; this may be a mechanism for As-induced diseases, as inflammation is involved in the pathogenesis of many chronic diseases, including CVD, metabolic syndrome [5], CKD [6], and cancer [7].
What organs arsenic affects?
Arsenic affects a broad range of organs and systems including:
- Skin.
- Nervous system.
- Respiratory system.
- Cardiovascular system.
- Liver, kidney, bladder and prostate.
- Immune system.
- Endocrine system.
- Developmental processes.
How long does arsenic stay in your system?
Both inorganic and organic forms leave your body in your urine. Most of the inorganic arsenic will be gone within several days, although some will remain in your body for several months or even longer. If you are exposed to organic arsenic, most of it will leave your body within several days.
Where does arsenic accumulate in the body?
Absorbed arsenic accumulates in the liver, kidneys, heart and lungs, with smaller amounts in the muscles, nervous system, gastrointestinal tract, spleen, and lungs. Arsenic is deposited in the keratin-rich tissues: nails, hair, and skin. Mee’s lines occur in the fingernails and toenails.
What foods help remove arsenic from the body?
Dark Leafy Greens: Spinach, kale, and collard-type plants supply the body with organic and easily absorbed minerals essential to detoxification. High Fiber Foods: Apples, lentils, pears, and raw nuts are all high in fiber. A high fiber diet helps keep the bowels unblocked and bids toxins in the colon.
What are the effects of arsenic exposure?
Chronic oral exposure to elevated levels of inorganic arsenic has resulted in gastrointestinal effects, anemia, peripheral neuropathy, skin lesions, hyperpigmentation, and liver or kidney damage in humans.
Does arsenic exposure cause kidney cancer?
The kidney is not the most sensitive target organ for chronic arsenic toxicity as other organ systems may be affected at lower doses. There is limited strength of association between chronic arsenic exposure and renal cancer [IARC 2004; NRC 2000].
What is the most sensitive endpoint from arsenic exposure?
The most sensitive endpoint from arsenic exposure is dermal effects. While several studies may identify effects on other endpoints at the same exposure level that produces dermal effects, the database for dermal effects is stronger than for effects on other endpoints [ATSDR 2007]
How does arsenic exposure affect pregnancy?
In particular, fetal mortality and preterm birth increased as exposure to arsenic increased. It was also found that exposure to arsenic during pregnancy affects urine excretion and the distribution of metabolites, it affect the development of the fetus.