Can you survive VOD?
The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%.
How serious is VOD?
In most cases, VOD is not severe, and the damage to the liver can be reversed. But serious VOD can be life-threatening. In this case, extra fluid in the abdomen puts pressure on the lungs, making it difficult to breath.
What is the most serious complication of hematopoietic stem cell transplant?
Abstract. Hematopoietic stem cell transplantation is a recognized treatment for hematological diseases such as leukemia and lymphoma, certain solid organ tumors, and a limited number of immunologic disorders. The major risks associated with this procedure are infections and development of graft-vs-host disease.
What is VOD illness?
Hepatic sinusoidal obstruction syndrome (SOS), also called veno-occlusive disease (VOD), is a systemic endothelial disease that typically presents in the days or weeks after hematopoietic cell transplantation (HCT) with refractory thrombocytopenia, hepatomegaly, ascites, and jaundice, and it can rapidly progress to …
What are the symptoms of VOD?
Symptoms of VOD include:
- jaundice. Close. jaundice. A condition in which the skin and whites of the eyes become yellow and urine is dark yellow.
- liver tenderness (under the ribs on the right side of the body)
- ascites. Close. ascites. Abnormal buildup of fluid in the abdomen.
- sudden weight gain.
- liver enlargement.
- liver failure.
How do you diagnose VOD?
The gold standard for VOD diagnosis is histologically through a liver biopsy. However, the test can be dangerous in transplant recipients who are neutropenic or thrombocytopenic. Ultrasound is sometimes used as an alternative, but findings may be vague.
How common is VOD?
VOD can occur in as high as 70% of patients and is the most common hepatic complication in the immediate post-transplant period. Along with infections and graft-versus-host disease, it is also one of the most common causes of death after transplant.
Why do stem cell transplants fail?
Graft Failure Sometimes, the donor’s stem cells fail to grow and replace the patient’s blood cells after the transplant. This is called graft failure. The most common cause is that the patient’s immune system recognizes the donor’s cells as foreign and attacks them.
What is VOD after bone marrow transplant?
Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is a rare complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and ascites, occurring after high-dose chemotherapy, hematopoietic stem cell transplantation (HSCT) and, less commonly, other conditions.
What is the incidence of hepatic VOD after hepatic stem cell transplantation?
Hepatic VOD can occur after autologous or allogeneic HSCT, regardless of the underlying disease, stem cell source, or type of pre-transplant conditioning. The incidence of hepatic VOD after HSCT varies from 0 to 77%, depending on the risk of the patient cohort; and the median incidence is 13.3%[1].
Is veno-occlusive disease a complication of hematopoietic stem cell transplantation?
This article has been cited byother articles in PMC. Abstract Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a major complication of hematopoietic stem cell transplantation and it carries a high mortality.
What is the most common hepatic complication in stem cell transplants?
Veno-Occlusive Disease Is the Most Common Hepatic Complication in Stem Cell Transplants. Although blood and marrow transplants can save patients’ lives, they can also result in numerous complications, including infections, renal failure, and liver complications, such as veno-occlusive disease (VOD).
What are the possible complications of hepatic veno-occlusive disease (VOD)?
Hematopoietic stem cell transplantation (HSCT) is a standard therapeutic modality for many different malignant and non-malignant diseases. However, complications from HSCT may result in severe morbidity and mortality. Major complications of HSCT include hepatic veno-occlusive disease (VOD), also known as hepatic sinusoidal obstruction syndrome.