What is the PKC pathway?
Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression.
What is PKC responsible for?
Protein kinase C (PKC) family members regulate numerous cellular responses including gene expression, protein secretion, cell proliferation, and the inflammatory response. The basic protein structure includes an N-terminal regulatory region connected to a C-terminal kinase domain by a hinge region.
How does PKC cause contraction?
PKC may also phosphorylate the actin-binding protein calponin, and thereby reverses its inhibition of actin-activated myosin ATPase, allows more actin to interact with myosin, and increases VSM contraction (Figure 1.1) [2].
What type of kinase is PKC?
serine–threonine kinases
Protein Kinase C (PKC) is a family of serine–threonine kinases found in most cell types whose activity has a strong influence on a wide variety of signal transduction events.
What does PKA do in cAMP pathway?
PKA phosphorylates numerous metabolic enzymes, including glycogen synthase and phosphorylase kinase, which inhibits glycogen synthesis and promotes glycogen breakdown, respectively, and acetyl CoA carboxylase, which inhibits lipid synthesis. PKA also regulates other signaling pathways.
Is PKA a serine threonine kinase?
The PKA C subunit is a classic example for a Ser/Thr kinase with serine specificity and this preference is highly conserved among different species [15].
What does PKC theta stand for?
The novel protein kinase C (PKC) isoform, PKC theta, is selectively expressed in T lymphocytes and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells. Productive engagement of T cells by antigen-presenting cells (APCs) results in recruitment of PKC theta to th …
What is the function of PKC Tetha?
Protein kinase C theta is a downstream effector of lymphocyte specific protein tyrosine kinase p56 (Lck) and cooperatively promotes HIV transcription. PKC-tetha sets the threshold for T-cell activation by positively regulating both the cytokine responses and the adhesive capacities of T lymphocytes.
What is the function of PKC?
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
What is the role of protein kinase C-theta in antitumor-mediated costimulation?
The protein kinase C theta transduction pathway is identified as a main regulator of the NKG2D-mediated costimulation of antitumor Vgamma9Vdelta2 cytolytic T cell responses. Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. Meta-analysis of gene-disease association. (HuGE Navigator)