What is the EAE model?
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis. This model is produced by administering a myelin basic protein peptide (MBP) fragment that induces an autoimmune response directed to the myelin sheath surrounding motor neurons.
Is EAE a good model for MS?
Experimental Autoimmune Encephalomyelitis (EAE) is a widely-accepted model of demyelinating diseases, such as multiple sclerosis (MS).
What is EAE induction?
Actively induced EAE consists of an induction phase and an effector phase. The induction phase of the disease involves the priming of myelin epitope–specific CD4+ T cells following immunization with myelin proteins or peptides in complete Freund’s adjuvant (CFA).
What is MOG EAE?
MOG-induced EAE Efficacy Model for MS Research Experimental autoimmune encephalomyelitis (EAE) is primarily used as a non-clinical model of autoimmune inflammatory diseases of the CNS, and resembles many aspects of human Multiple Sclerosis (MS).
How do you make an EAE?
Ace Your EAE Application in 5 Ways
- 1) 600-character write-up (Aptitude and Interest)
- 2) 1000-character write-up (Talent & Achievements)
- 3) The order of your choices matter.
- 4) Bring a relevant portfolio.
- 5) Arm yourself with knowledge and be prepared to show and tell.
What is EAE research?
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used experimental model for the human inflammatory demyelinating disease, multiple sclerosis (MS).
How is EAE induced?
EAE is induced in C57BL/6 mice1 by immunization with an emulsion of MOG35-55 or MOG1-125 in complete Freund’s adjuvant (CFA), followed by administration of pertussis toxin in PBS, first on the day of immunization and then again the following day.
How does MOG cause EAE?
The pathophysiology of EAE is based on the reaction of the immune system against brain-specific antigens. This reaction induces inflammation and destruction of the antigen carrying structures, resulting in neurological and pathological features comparable which those observed in MS patients.
What virus causes encephalitis?
The most common causes of viral encephalitis are herpes simplex virus types 1 and 2, varicella zoster virus and enteroviruses, which cause gastrointestinal illness. Encephalitis can also result from certain viruses carried by mosquitoes, ticks and other insects or animals such as: West Nile virus.
What is the difference between autoimmune encephalitis and encephalitis?
Traditional encephalitis is caused by a virus or bacteria, the NLM says. But autoimmune encephalitis occurs when the body’s immune system unexpectedly creates antibodies to attack the brain, says Eric Lancaster, MD, PhD, an Assistant Professor of Neurology at Penn Neuroscience Center.