What is the Cockcroft-Gault formula?
The Cockcroft-Gault formula reads: GFR estimate = (140 − age (years) × weight (kg) × constant/serum creatinine(μmol/L)The published constants are 1.23 for males of any age, and 1.05 for females of any age[4].
Why is Cockcroft-Gault equation is used for?
The Cockcroft-Gault (CG) equation provides an estimate of creatinine clearance and is the equation most commonly used to determine drug dosages in patients with impaired kidney function.
Is Cockcroft-Gault formula accurate?
The Cockcroft and Gault formula was further shown to be a reliable estimate of GFR in twelve studies comparing the results of the estimate with methods giving true GFR values (inulin; 2 studies with 196 patients) or more accurate GFR values (10 studies with 1218 patients; 3 studies with 99m-Tc-DPTA; 4 studies with 51Cr …
Should we continue to use the Cockcroft-Gault formula?
Conclusions: CG still has an interest in screening the decline in renal function in subjects with normal SCr who are at risk, such as diabetics and stage 1 and 2 CKD patients, as well as healthy subjects enrolled in clinical trials and pharmacokinetic studies.
How is renal clearance calculated?
Ask yourself, “What would the renal clearance be if the ClRen depended only on glomerular filtration?” ClRen = GFR * fu = (125 ml/min) * (0.5) = 62.5 ml/min. The actual value (ClRen = 10 ml/min) is lower than this calculated value based only on filtration, i.e. less drug is being removed from the body than we expected.
What is normal range for Cockcroft-Gault?
The normal range of CrCl is 110 to 150mL/min in males and 100 to 130mL/min in females. [15] Serum creatinine level for men with normal kidney function is approximately 0.6 to 1.2mg/dL and between 0.5 to 1.1 mg/dL for women.
What is a normal creatinine clearance level?
Normal Results Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are: Male: 97 to 137 mL/min (1.65 to 2.33 mL/s). Female: 88 to 128 mL/min (1.496 to 2.18 mL/s).
When do you not use Cockcroft-Gault?
The Cockcroft-Gault (CG) formula is provided on this website for research purposes only. It should not be used for drug dosing or to estimate GFR. The best way to determine drug dosing is with the CKD-EPI Creatinine Equation (2009) or the MDRD Study. Both have been shown to be more accurate than the CG formula.
What is normal GFR African American?
An eGFR score of 60 or higher indicates normal functioning. An eGFR score of under 60 may indicate kidney disease. An eGFR score of under 15 may indicate kidney failure.
How do you use Cockcroft Gault equation?
Cockcroft Gault. Cockcroft Gault equation is used to estimate the creatinine clearance rate that is used to test the kidney functioning. The equation was introduced by Cockcroft and Gault and uses serum creatinine, weight and age of the patient. If it is for female, a constant 0.85 is multiplied with the result.
What is the accuracy of the Cockroft-Gault equation for creatinine clearance?
The Cockroft-Gault Equation typically overestimates creatinine clearance by approximately 10 to 30%. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine.
Is the Cockcroft and Gault formula valid for renal function estimation?
The Cockcroft and Gault formula has been validated by long usage but the derivation appears logically insecure. Nevertheless, its role in estimating renal function at the bedside is established. The Cockroft and Gault formula for estimation of creatinine clearance: a friendly deconstruction
Does the Cockcroft-Gault assay increase drug dosing recommendations?
The assay used to develop the Cockcroft-Gault was likely 10-20% higher than current methods, therefore use of estimated creatinine clearance calculated using the Cockcroft-Gault will lead to higher drug dosing recommendations than was intended in the original pharmacokinetic studies.