What does the term down regulation mean?
Downregulation: An decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or another agent.
What is down regulation example?
An example of downregulation is the cellular decrease in the expression of a specific receptor in response to its increased activation by a molecule, such as a hormone or neurotransmitter, which reduces the cell’s sensitivity to the molecule. This is an example of a locally acting (negative feedback) mechanism.
What is down regulation psychology?
Down regulation is the process by which a cell decreases the number of receptors to a given hormone or neurotransmitter to reduce its sensitivity to this molecule. This is a locally acting negative feedback mechanism. An increase of receptors is called up regulation.
What does downregulation of receptors mean?
Receptor downregulation is characterized by a decrease in total receptor number in the cell due to endocytosis and subsequent degradation of the receptors caused by long-term exposure to agonists (see Fig. 5-7).
What is down regulation in pharmacology?
Downregulation • Downregulation specifically refers to a reduction in the total number of receptors available to be stimulated due to prolonged receptor activation (e.g. by chronic treatment with a pharmacological agonist drug or prolonged inhibition of metabolism of a neurotransmitter).
What does down regulate mean IVF?
Downregulation is usually the first stage of a high stimulation IVF treatment protocol – it is the name given to the process of using medication to shut down your natural menstrual cycle, in effect causing an artificial menopause.
What is down-regulation in pharmacology?
Why does down-regulation occur?
Downregulation (i.e., decrease in number) is the inverse of upregulation. It occurs due to repeated or long-term administration of an agonist. Along with downregulation, desensitization of the receptor to the drug may also occur.
What is the difference between down regulation and upregulation?
In up-regulation, the number of receptors increases in response to rising hormone levels, making the cell more sensitive to the hormone and allowing for more cellular activity. When the number of receptors decreases in response to rising hormone levels, called down-regulation, cellular activity is reduced.
What causes up and down-regulation?
What is down-regulation quizlet?
Down-regulation. prolonged exposure to high hormone concentrations can decrease the # of receptors of that hormone; desensitizes the target cells, so they response less vigoursly to hormonal stimulation, preventing them from overreacting to persistently high hormone levels.
Do you get a period during down regulation?
Is it normal to bleed during down-regulation? Yes, you are likely to bleed while taking the medication. This bleeding is similar to a period if you started on day 21. If you started the down regulation on day two of your cycle, you might not have a further bleed, or it may just be light spotting.