What does ACSL1 mean?

What does ACSL1 mean?

ACSL1 is a programmable mediator of insulin sensitivity and cellular lipid content. long-chain acyl-CoA synthetase isoform 1 (ACSL1) deficiency in the heart activated mTORC1, thereby inhibiting autophagy and increasing the number of damaged mitochondria.

What is acyl CoA synthetase 1 deficiency?

Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function ACSL1 is a programmable mediator of insulin sensitivity and cellular lipid content. long-chain acyl-CoA synthetase isoform 1 (ACSL1) deficiency in the heart activated mTORC1, thereby inhibiting autophagy and increasing the number of damaged mitochondria.

What does the ACSL5 gene do?

The ACSL5 gene resides on human chromosome 10. The encoded protein product converts free long chain FAs with 16–18 carbons, such as palmitic acid, palmitoleic acid, oleic acid and linoleic acid, to fatty acyl-coenzyme A and is involved in FA intake and synthesis of triacylglycerol ( Senkal et al., 2017 ).

What is the role of ACSL in the pathophysiology of cancer?

ACSL family members are responsible for the activation of FAs and play differential roles in the development of cancers. ACSL1 is involved in the TNFα-mediated pro-inflammatory phenotype and mainly facilitates cancer progression.