What are the signs and symptoms of Castleman disease?

What are the signs and symptoms of Castleman disease?

Signs of multicentric Castleman disease (MCD) include:

• Fever.
• Night sweats.
• Fatigue (extreme tiredness)
• Appetite and weight loss.
• Abnormally large lymph nodes, typically in the neck, armpit, collarbone, and groin.
• Enlarged spleen or liver.
• Anemia (low amount of red blood cells)

Is Castleman disease fatal?

Multicentric Castleman disease may lead to life-threatening infections or organ failure. People who also have HIV/AIDS generally have the worst outcomes. Having either variety of Castleman disease may increase your risk of lymphoma.

What kind of doctor treats Castleman’s disease?

You may be referred to a doctor who specializes in treating blood disorders (hematologist).

Is Castleman disease rare?

Castleman disease is a rare disorder that involves an overgrowth of cells in your body’s lymph nodes.

Is Castleman’s disease a cutaneous disease?

Castleman’s disease is a rare disease of the lymph nodes and related tissues, presenting as angiofollicular or giant lymph node hyperplasia. Although various skin manifestations have been reported to occur in Castleman’s disease, a comprehensive study of cutaneous disorders in Castleman’s disease is lacking.

How common is HHV-8 in Castleman disease?

Studies have found that HHV-8 is present in nearly all HIV-positive people who have Castleman disease, and in about half of HIV-negative people with Castleman disease. Castleman disease can affect people of any age. But the average age of people diagnosed with unicentric Castleman disease is 35.

Can Castleman’s disease of the submandibular node be isolated?

Isolated Castleman’s disease of the submandibular node is rare and a thorough clinical and histological examination is necessary to rule out the systemic form of the disease and other diseases with manifestations as a cervical lymph node enlargement. Keywords: Angiolymphoid hyperplasia, Castleman’s disease, cervical lymphadenopathy INTRODUCTION

What causes Castleman disease (CD)?

The exact underlying cause of Castleman disease (CD) is poorly understood. However, some scientists suspect that an increased production of interleukin-6 (IL-6) by the immune system may contribute to the development of CD.