Should metolazone be given before Lasix?
Metolazone is recommended to be taken in the morning due to its prolonged absorption and duration of action. In patients resistant to loop diuretics, metolazone should be given one hour before the regular morning dose of furosemide.
Why do you give metolazone 30 minutes before furosemide?
Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.
Can you give metolazone and Lasix together?
You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium.
When do you start metolazone?
Metolazone is an oral thiazide-type diuretic commonly used for this purpose. Due to its delayed absorption, some clinicians suggest that metolazone be given 30-60 minutes prior to the loop diuretic. However, the efficacy and safety of such a strategy has not been investigated despite its added complexity.
When do you add metolazone to Lasix?
For patients who respond poorly to large dosages of loop diuretics, consider adding 5 to 10 mg of metolazone (Zaroxolyn) one hour before the dose of furosemide once or twice a week as tolerated.
Why is metolazone given with furosemide?
Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention. High doses of furosemide can be avoided in many cases, a factor of particular advantage in ambulatory long term therapy and in patients with decreased kidney function.
How do you take metolazone?
Metolazone comes as a tablet to take by mouth. It is usually taken once a day. Take metolazone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
What is the difference between Lasix and metolazone?
Lasix (furosemide) and Zaroxolyn (metolazone) are diuretics (water pills) used treat excess accumulation of fluid or swelling of the body (edema) and high blood pressure (hypertension). Lasix is a brand name for furosemide. Zaroxolyn is a brand name for metolazone.
What is metolazone given for?
Metolazone is used to treat fluid retention (edema) and swelling that is caused by congestive heart failure, kidney disease, or other medical conditions . Metolazone is also used alone or together with other medicines to treat high blood pressure (hypertension).
Can metolazone be given IV?
Oral metolazone appears to be equally effective as intravenous chlorothiazide. In practice, metolazone may have an advantage due to reduced cost and longer half-life.
What’s the difference between Lasix and metolazone?