Is lichen planus linked to other diseases?
Lichen planus is a cell-mediated immune response of unknown origin. It may be found with other diseases of altered immunity, such as ulcerative colitis, alopecia areata, vitiligo, dermatomyositis, morphea, lichen sclerosis, and myasthenia gravis.
What causes lichen planus like keratosis?
The exact cause of lichenoid keratosis isn’t known. It may be due to an inflammatory reaction. This happens when your immune system mistakenly attacks the skin. This reaction may be triggered by excess sun or UV light exposure, skin irritation, and some medications.
What blood pressure medications cause lichen planus?
Medications commonly reported to trigger a lichenoid drug eruption include: Antihypertensives – ACE inhibitors, beta-blockers, nifedipine, methyldopa. Diuretics – hydrochlorothiazide, frusemide, spironolactone. Non-steroidal anti-inflammatory drugs (NSAIDs)
Is lichen planus an autoimmune problem?
Lichen planus is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa, genital mucosa, scalp, and nails.
Is lichen planus-like keratosis?
Lichen planus-like keratosis (LPLK) is an involuting cutaneous lesion often presenting between the fifth and seventh decades of life. These lesions typically appear abruptly as a solitary macule, papule, or plaque that continuously evolves as it undergoes regression.
Can lichen planus cause fatigue?
Immune modulators – such as imiquimod and levamisole may be advised by a specialist if lichen planus is severe. These work with the body’s immune system to help fight damage to the skin. Skin irritation, headache, nausea and tiredness can be side-effects.
Is lichen planus related to lupus?
Lupus erythematosus lichen planus (LE-LP) overlap syndrome remains an uncommon diagnostic entity, combining both the histologic and clinical features of lupus erythematosus and lichen planus. A rare and challenging diagnosis, clinicopathologic correlation is essential for accurate and timely identification.
Is lichen planus like keratosis serious?
Lichen Planus-Like Keratosis Can Be Very Serious. A lichen planus-like keratosis is a precancerous skin growth caused by sun damage. They are sometimes difficult to see, they feel rough to the touch and are sometimes scaly.
What is the pathophysiology of lichenoid keratosis?
Lichenoid keratosis is a small, inflamed macule or thin pigmented plaque, usually solitary, with a lichenoid tissue reaction on histology. Lichenoid keratosis is also known as benign lichenoid keratosis, solitary lichen planus, lichen planus-like keratosis and involuting lichenoid plaque. It is one of the causes of atypical solar lentigo.
How is lichen planus-like keratosis (PLK) diagnosed?
The first being a biopsy of a solar lentigo and 5 years later, after the lesion had demonstrated a clinical change into a solitary lichen planus ‐like keratosis. Lichen planus-like keratosis is a great masquerader with a differential diagnosis including basal cell carcinoma, squamous cell carcinoma and melanoma.
What causes lichen planus?
What causes most cases of lichen planus remains unclear. One theory is that lichen planus is an autoimmune disease. This means the person’s immune system reacts as though the skin and other parts of the body are foreign. When this happens, the body starts to attack itself.