How fast can you infuse daptomycin?
CUBICIN should be administered intravenously either by injection over a two (2) minute period or by infusion over a thirty (30) minute period. CUBICIN 4 mg/kg should be administered intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
How do you administer daptomycin?
In adults, Daptomycin is given by intravenous infusion (see section 6.6) and administered over a 30-minute period or by intravenous injection (see section 6.6) and administered over a 2-minute period.
How long does it take to reconstitute daptomycin?
Allow the wetted product to stand undisturbed for 10 minutes. Gently rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution.
Is daptomycin IV push?
Daptomycin was originally approved by the US Food and Drug Administration (FDA) in September 2003 as a once-daily 30-minute intravenous (IV) infusion. In November 2010, the FDA approved a 2-minute rapid IV injection based on data from 2 consecutive pharmacokinetic and safety evaluation studies.
What should I monitor with daptomycin?
Patients receiving daptomycin should be monitored for the development of muscle pain or weakness. Consideration should be given to temporarily suspending agents associated with rhabdomyolysis.
Can daptomycin cause C diff?
Adverse Effects It is important to note that prolonged use of daptomycin can develop a superinfection such as Clostridium difficile-associated diarrhea (CDAD) and pseudomembranous colitis. The incidence of CDAD has been observed greater than two months after treatment with daptomycin.
How much does daptomycin cost?
Daptomycin is administered by a healthcare professional as a slow injection or as an intravenous infusion. Daptomycin cost is normally $1,490.36 for 3, 500MG Solution Reconstituted at full price. Daptomycin is administered by healthcare professionals.
Is daptomycin a high risk drug?
Elderly patients are at an increased risk of daptomycin toxicity due to age-related changes in renal function or factors that may enhance the exposure to the medication. However, no dosage adjustments are recommended for patients with a creatinine clearance greater than 30 mL/min.
Can daptomycin cause liver damage?
Conclusion: Although hepatic abnormalities caused by daptomycin are rare, a handful of cases with daptomycin-induced liver injury have been reported in the literature. Of note, in most cases, patients on daptomycin therapy developed liver damage with elevations in CK levels.
Is daptomycin stronger than vancomycin?
The hypothesis of our trial is that daptomycin treatment is superior to vancomycin treatment in reducing the 60-day all-cause mortality rate from BSIs due to MRSA with high vancomycin MICs from 25 to 10%.
Can daptomycin make you tired?
Call your doctor right away if you develop chest pain, dry cough, fever, general feeling of tiredness or weakness, rapid breathing, trouble breathing, or skin rash after receiving this medicine.
What are the side effects of daptomycin?
Nausea, vomiting, constipation, diarrhea, headache, dizziness, trouble sleeping, increased sweating, or pain/redness/swelling at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Why is daptomycin so expensive?
Why are 36 ranges so expensive? Since manufacturers build 30” models in much larger quantities, this helps to bring the pricing down. Because of this, manufacturers make a point of including nicer features on 36” wide models and these usually entail things like higher BTU output on the burners.
What conditions does daptomycin treat?
blood infection caused by Staphylococcus aureus bacteria
How to administer daptomycin?
To minimize foaming,AVOID vigorous agitation or shaking of the vial during or after reconstitution.
How to dose daptomycin?
approved dosing recommendations for daptomycin are 4 mg/kg once every 24 hours when treating complicated skin and skin structure infections (cSSSI) and 6 mg/kg once every 24 hours when treating S. aureus bacteremia, however recent literature recommends doses as high as 8 – 12 mg/kg