How does citalopram work in the brain?
Citalopram is used to treat depression. Citalopram is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.
What is the mechanism of action of citalopram?
The mechanism of action of citalopram results from its inhibition of CNS neuronal reuptake of serotonin (5-HT) Label. The molecular target for citalopram is the serotonin transporter (solute carrier family 6 member 4, SLC6A4), inhibiting its serotonin reuptake in the synaptic cleft 13.
What is the difference between Escitaloprám and citalopram?
Citalopram was approved in 1998 for the treatment of depression. It is produced as a racemate, this means that it is a mixture of two stereoisomers: R-citalopram and S-citalopram. Escitalopram is only one enantiomer, s-citalopram. This drug was approved in 2002 and was developed with the goal of better tolerability.
What does it feel like to be on citalopram?
Starting out with some side effects The first day of taking the pills, they made me feel nauseous. A few days later it got much worse and I was very tired and too dizzy to stand up. I had to call in sick to work and just lay on my sofa (crying a lot because I felt so awful).
Does citalopram reduce stress?
An SSRI like Celexa can prevent serotonin from being reabsorbed back into the nerve cells that previously released it. This simple act can improve mood, reduce feelings of anxiety, and decrease the severity of panic attacks and other panic disorder symptoms.
When does citalopram reach its peak?
Peak blood levels of citalopram occur within 1 to 6 hours, with an average time of 4 hours. Initial effects for depression seen within 1 to 2 weeks; however, it may take up to 4-6 weeks of regular dosing before the maximum antidepressant effects are seen.
How quickly is citalopram absorbed?
After oral administration, citalopram is rapidly absorbed, with peak plasma levels observed approximately after 1–4 h and a plasma half-life of approximately 35 h after administration [8–10].
Is Lexapro stronger than Prozac?
When considering Prozac vs Lexapro, both medications are approved to treat major depressive disorder (MDD). A 2014 study found that Lexapro was more effective than Prozac in treating severe periods of depression.
Can citalopram make you emotionless?
On antidepressant medication, it is possible that you might experience a sense of feeling numb and less like yourself. Though the symptoms of depression have decreased, there may be a sense that other emotional responses – laughing or crying, for example – are more difficult to experience.