How does androgen deprivation therapy ADT work?

How does androgen deprivation therapy ADT work?

Androgen deprivation therapy (ADT) is a type of hormone therapy commonly used in treating men with prostate cancer. It controls cancer cells by reducing androgen levels in the body. This can affect cancer cells and the new blood vessels that supply them.

What are ADT medications?

Hormone therapy (also called androgen deprivation therapy or ADT) is part of the standard of care for advanced and metastatic prostate cancer. ADT is designed to either stop testosterone from being produced or to directly block it from acting on prostate cancer cells.

What is androgen deprivation therapy used for?

Androgen deprivation therapy (ADT) is widely used in the community setting to treat men with clinically localized prostate cancer, biochemical recurrence after radical prostatectomy, locally advanced disease, lymph node metastases, and asymptomatic metastatic disease.

How quickly does PSA drop after hormone therapy?

Median PSA at the end of hormonal therapy for all patients was 0.2 ng/mL (range: 0 – 96.2). A total of 744 patients (70%) reached a PSA-CR at the end of hormonal therapy. The time to reach PSA nadir was 3.7 months, ranging from 0.8 to 8.2 months. With a median follow-up of 7.2 years, higher rates of BF (56% vs.

What is ADT for prostate?

Prostate cancer needs testosterone to grow. Reducing how much testosterone your body makes may slow the cancer’s growth or shrink the cancer temporarily. Testosterone is an androgen (male sex hormone), so this treatment is called androgen deprivation therapy (ADT).

What is ADT mental health?

Boston—Androgen-deprivation therapy (ADT) increases the risk of depression and mental health treatment in patients being treated for localized prostate cancer (PCa), according to new research.

Does testosterone return after ADT?

After ADT, many patients had normal testosterone levels (>6 nmol/L) until 6 weeks, and testosterone recovery reached 35% at 12 weeks (mean, 11.4 nmol/L), 85% at 18 weeks, and 89% at 24 weeks. The median time for testosterone recovery was 13 weeks.