Does meropenem need renal adjustment?
Renal failure/dialysis: Adjustment required – 750 mg every 12 hours for creatinine clearance of 20–40 ml/min; 500 mg every 12 hours for creatinine clearance <20 ml/min.
When should you not use meropenem?
Who should not take MEROPENEM?
- diarrhea from an infection with Clostridium difficile bacteria.
- decreased blood platelets.
- lesion of the brain.
- seizures.
- chronic kidney disease stage 4 (severe)
- chronic kidney disease stage 5 (failure)
- kidney disease with likely reduction in kidney function.
How long can you take meropenem?
Clinical practice guidelines recommend meropenem for 4 to 7 days for severe or high-risk community-acquired infections or complicated health-care associated infections.
Is meropenem a strong antibiotic?
Meropenem (Merrem) is considered one of the stronger antibiotics. It works against many types of bacteria and treats severe or complicated infections when other antibiotics may not be enough.
Can meropenem cause high creatinine?
Meropenem breakpoints for Streptococcus pneumoniae and Haemophilus influenzae in meningitis are 0.25 mg/l (Susceptible) and 1 mg/l (Resistant)….Meropenem 1g powder for solution for injection/infusion.
| Creatinine clearance (ml/min) | Dose (based on “unit” dose range of 500 mg or 1 g or 2 g, see table above) | Frequency |
|---|---|---|
| <10 | half of one unit dose | every 24 hours |
Which antibiotic is safe in renal failure?
Drugs that should not, in general, be given to patients in CKD stage 3 or higher (GFR under 60 mL/min) include methotrexate, enoxaparin, metformin, and lithium (table 3)….Table 2.
| Class | Dependent on renal function | Independent of renal function |
|---|---|---|
| Antibiotics | Ciprofloxacin, levofloxacin | Moxifloxacin |
What is meropenem 500 mg used for?
Meropenem injection is used to treat skin and abdominal (stomach area) infections caused by bacteria and meningitis (infection of the membranes that surround the brain and spinal cord) in adults and children 3 months of age and older. Meropenem injection is in a class of medications called antibiotics.
What drugs damage kidneys?
Illegal Drugs Most street drugs, including heroin, cocaine and ecstasy can cause high blood pressure, stroke, heart failure and even death, in some cases from only one use. Cocaine, heroin and amphetamines also can cause kidney damage.