What is C677T MTHFR?

What is C677T MTHFR?

The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) with the epidemiology of the polymorphism of the C677T that varies dependent on the geography and ethnicity.

What does heterozygous mean MTHFR?

People with a mutation in 1 MTHFR gene are are said to be heterozygous; if mutations are present in both genes, the person is said to be homozygous or compound heterozygous for the mutation(s).

Can you have a baby with thrombophilia?

In general, women with thrombophilia do not have more pregnancies with complications, but late pregnancy loss in the first or later in the second trimester, placental abruption, and incomplete fetal development are the most frequent. Also, thrombophilia may be clots implicated in preeclampsia.

How does thrombophilia cause miscarriage?

When the fertilized egg implants into the uterine decidua, it comes into contact with the maternal circulation, and this connection is crucial to a successful pregnancy. Prothrombotic states such as thrombophilia may interfere with this process, producing thrombosis that leads to miscarriage.