What does myogenic autoregulation mean?
The myogenic theory of autoregulation states that an intrinsic property of the blood vessel, or more specifically, vascular smooth muscle, regulates vascular tone in response to changes in intraluminal pressure.
What is the purpose of myogenic mechanism?
The myogenic mechanism is how arteries and arterioles react to an increase or decrease of blood pressure to keep the blood flow constant within the blood vessel. Myogenic response refers to a contraction initiated by the myocyte itself instead of an outside occurrence or stimulus such as nerve innervation.
What is myogenic autoregulation of GFR?
The myogenic mechanism refers to the intrinsic ability of arteries to constrict when blood pressure rises and to vasodilate when it decreases. This phenomenon modulates changes in RBF and GFR when blood pressure varies.
What is metabolic autoregulation?
Autoregulation is a manifestation of local blood flow regulation. It is defined as the intrinsic ability of an organ to maintain a constant blood flow despite changes in perfusion pressure.
What effect would an increase in mean arterial pressure have on the intrinsic myogenic response?
Myogenic mechanisms are intrinsic to the smooth muscle blood vessels, particularly in small arteries and arterioles. If the pressure within a vessel is suddenly increased, the vessel responds by constricting.
What triggers renal autoregulation?
Renal autoregulation is achieved primarily by a unique orchestrated action of two major mechanisms: the myogenic response and the macula densa tubuloglomerular feedback (MD-TGF) response.
What affects autoregulation?
Other relevant clinical factors impacting autoregulation include (1) inhalational anesthetics (autoregulation impaired in a dose-dependent fashion), (2) preexisting hypertension (the autoregulation curve is shifted to the right with a narrower plateau and therefore blood pressure required clinically to maintain …
What causes autoregulation?
One proposed mechanism of autoregulation is that parallel changes in the CPP and the vascular wall stretch, caused by variations in mean arterial pressure (MAP) or in intracranial pressure (ICP), produce reflex changes in arteriolar smooth muscle tone designed to adjust the caliber of the vessels and maintain the CBF …
What is the Myogenic Theory of autoregulation?
The myogenic theory of autoregulation states that an intrinsic property of the blood vessel, or more specifically, vascular smooth muscle, regulates vascular tone in response to changes in intraluminal pressure. The myogenic response of small coronary arerioles does not depend on the presence of an intact, functional endothelium.
What is the myogenic response?
By definition, the myogenic response is the contraction of a blood vessel that occurs when intravascular pressure is elevated and, conversely, the vasodilation that follows a reduction in pressure. Over the last several decades numerous investigators have demonstrated the importance of the myogenic …
What is the vascular myogenic mechanism?
The vascular myogenic mechanism is thought to be responsible for the development of spontaneous vascular tone and for the constriction of a blood vessel in response to intravascular pressure elevation and dilation in response to pressure reduction.
What is autoregulation?
What is autoregulation? Autoregulation is a biological process in which an internal adaptive mechanism works to adjust (or mitigate) an animal’s response to stimuli. For example, the autoregulation process results in the maintenance of blood flow to tissues at a certain level despite variations in blood pressure or metabolism.