How do you use Mitosol?

How do you use Mitosol?

Place the vial on a firm, flat surface. Push the syringe down and spike the vial, then inject the sterile water down into the vial. Invert and shake well to insure complete drug reconstitution. Once the Mitosol is reconstituted, it is time to soak the sponges.

How is mitomycin ophthalmic administered?

Mitomycin ophthalmic is a liquid medicine that is applied first to a tray of tiny sponges. The sponges will soak in the mitomycin for at least 60 minutes. Once the sponges are saturated with mitomycin, your surgeon will place the sponges directly onto your eye.

Is Mitosol the same as mitomycin?

Mitosol® is a sterile lyophilized mixture of mitomycin and mannitol, which, when reconstituted with Sterile Water for Injection, provides a solution for application in glaucoma filtration surgery. Mitosol® is supplied in vials containing 0.2 mg of mitomycin.

How do you reconstitute MMC?

DRUG RECONSTİTUTİON AND PHARMACOKİNETİCS The drug is available in a vial (2mg/ml and 10mg/ml). It is further reconstituted with normal saline either 5 ml for 2 mg/ml vial to make 0.4 mg/ml solution or 10 ml for 2 mg/ml vial to make 0.2 mg/ml solution [3]. MMC is delivered in solubilized form.

How do you mix mitomycin?

Reconstitution

1. Each vial contains a lyophilized mixture of mitomycin 0.2 mg and mannitol 0.4 mg.
2. To reconstitute, add 1 mL of sterile water for injection, then shake to dissolve.
3. If product does not dissolve immediately, allow to stand at room temperature until the product dissolves into solution.

How does antimetabolite work?

Antimetabolites are called a “cytotoxic” type of drug because they kill cells. They work by mimicking the molecules that a cell needs to grow. Cells are tricked into taking in the drugs and then using the antimetabolites instead of their normal building blocks of genetic material: RNA and DNA.

What is Mitomycin used for?

Mitomycin is a type of antibiotic that is only used in cancer chemotherapy. It slows or stops the growth of cancer cells in your body.

What is MMC eye surgery?

Mitomycin C (MMC) is an antimetabolite used during the initial stages of a trabeculectomy to prevent excessive postoperative scarring and thus reduce the risk of failure.

What is mitomycin C in eye surgery?

Mitomycin C is an antimetabolite applied between the sclera and conjunctiva during the initial stages of a trabeculectomy to prevent excessive post-operative scarring and thus reduce the risk of failure.

How do you make mitomycin C 0.02 eye drops?

Our preparation of the mitomycin-C includes mixing the drug with a sterile water diluent to achieve a starting concentration of 0.2 mg/ml. This is then diluted further with 2% lidocaine—the same lidocaine we would use in a retrobulbar block.

How is mitomycin C Prepared?