What is the ACADM gene?
ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids.
What does Acadm stand for?
acyl-CoA dehydrogenase medium chain.
How is MCAD inherited?
MCAD deficiency is inherited from both parents. Though both parents are carriers — each one has an abnormal gene — they typically don’t have symptoms of the condition. The affected child inherits two copies of the abnormal gene — one from each parent.
What is the function of medium chain acyl-CoA dehydrogenase enzyme?
Medium chain acyl-coA dehydrogenase deficiency (MCADD) is a genetic disorder caused by a lower than normal level of the medium chain acyl-coenzyme A dehydrogenase enzyme. This enzyme is involved in breaking down fat stores in the body to be used for energy.
Who has MCAD?
In the United States, the estimated incidence of MCAD deficiency is 1 in 17,000 people. The condition is more common in people of northern European ancestry than in other ethnic groups.
What is Macdd?
MCADD is a rare genetic condition where a person has problems breaking down fat to use as an energy source. This means that someone with MCADD can become very ill if their body’s energy demands exceed their energy intake, such as during infections or vomiting illnesses when they’re unable to eat.
What is medium chain triglyceride oil?
Medium chain triglycerides (MCTs) are partially man-made fats. The name refers to the way the carbon atoms are arranged in their chemical structure. MCTs are generally made by processing coconut and palm kernel oils in the laboratory.
What is MCAD in a baby?
Medium chain acyl CoA dehydrogenase deficiency (MCAD) is the most common inborn error of fatty acid oxidation. This condition may lead to cellular energy shortage and cause severe clinical events such as hypoketotic hypoglycemia, Reye syndrome and sudden death.
What are symptoms of MCAD?
Signs and symptoms of MCAD deficiency typically appear during infancy or early childhood and can include vomiting, lack of energy (lethargy), and low blood sugar (hypoglycemia). In rare cases, symptoms of this disorder are not recognized early in life, and the condition is not diagnosed until adulthood.
Can you get Vlcad as an adult?
Adults diagnosed with VLCAD deficiency have milder symptoms and typically do not develop metabolic crises.
What is Vlcad condition?
Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is a condition that prevents the body from converting certain fats to energy, particularly during periods without food (fasting).