Do radial glial cells guide migrating neurons?

Do radial glial cells guide migrating neurons?

Radial glial cells, which express glial fibrillary acidic protein (GFAP), play an important role in promoting the generation of neuronal progenitors and providing the migratory substrate during the neuronal migration (Tabata and Nakajima, 2003).

What are the migrating glial cells?

Glial cells generally leave their place of birth to migrate to positions where they control neuronal development or guarantee axonal isolation. In principle, cells can either migrate individually or can move as chains or groups of cells through the body.

What is nerve cell migration?

Neuronal migration is the method by which neurons travel from their origin or birthplace to their final position in the brain. There are several ways they can do this, e.g. by radial migration or tangential migration.

What do radial glial cells give rise to?

We show that these radial glial cells give rise to neurons, astrocytes, ependymal cells, and oligodendrocytes. More importantly, we show that these neonatal radial glial cells give rise to the SVZ astrocytes that maintain neurogenesis in the adult mammalian brain.

Are radial glial cells astrocytes?

). As a matter of fact, no molecule has been identified so far that would discriminate across species between astrocytes and radial glial cells. Thus, these cells are truly distinct from neuroepithelial cells and are as “astrocytic” as can be assessed by molecular and ultrastructural criteria.

What are radial cells?

Radial glia are specialized cells in the developing nervous system of all vertebrates, and are characterized by long radial processes. These processes facilitate the best known function of radial glia: guiding the radial migration of newborn neurons from the ventricular zone to the mantle regions.

In what formation do groups of migrating neurons migrate?

Neurons migrate to their correct anatomical position in the brain with the help of adhesion molecules. During embryogenesis, the long processes of radial cells create an organized, cellular scaffolding on which neurons can migrate to their final position in the brain shortly after they appear.

Where do neuroblasts migrate?

SVZ Neuroblasts Migrate through the Rostral Migratory Stream to the Olfactory Bulbs. The subventricular zone (SVZ) lining the lateral ventricles is one of the two largest neurogenic areas within the adult mouse brain.