How is halothane metabolized?

Current Concepts in Drug Metabolism and Toxicology Halothane is metabolized extensively in hepatocytes by CYP 2E1 and, to a lesser extent, via CYP 2A6 to form trifluoroacetyl chloride, which is chemically reactive and forms trifluoroacetyl adducts with proteins.

What is the common name of halothane?

Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to induce or maintain anaesthesia.

Is halothane a Haloalkane?

Halothane is a haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position. It has a role as an inhalation anaesthetic.

What is the MAC of halothane?

Halothane (Figure 1) is a nonflammable halogenated alkene with a blood/gas coefficient of 2.3 and an MAC in 100% oxygen of 0.74 and 0.29 in 70% nitrous oxide.

What is the antidote for halothane?

There is no specific antidote.

What does enflurane smell like?

It is a clear, colorless, volatile liquid at room temperature and pressure. It has an odor that has been described as ether-like or sweet.

How is enflurane metabolized?

Enflurane is oxidatively metabolized in the liver microsomes by CYP2E1 enzymes to give the unstable intermediate, 24, which upon dehydrohalogenation gives the corresponding acid chloride, 25. This acid chloride reacts rapidly with liver proteins to give the protein adducts (26) (Figure 14).

Why is halothane no longer used?

Halothane is a medication previously used for induction and maintenance of general anesthesia. After its large impact on medicine and anesthesia specifically, it has since fallen out of practice due to its side effect profile.

When do you use halothane?

Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.