What are the AAP guidelines for IVIG dosing in the treatment of neonatal jaundice?

What are the AAP guidelines for IVIG dosing in the treatment of neonatal jaundice?

The 2004 AAP guidelines suggest a dose range for IVIG of 500-1000 mg/kg. The author routinely uses 500 mg/kg infused intravenously over a period of 2 hours for Rh or ABO incompatibility when the total serum bilirubin levels approach or surpass the exchange transfusions limits.

Which is a preferred treatment for neonatal jaundice?

Phototherapy, intravenous immune globulin (IVIG), and exchange transfusion are the most widely used therapeutic modalities in infants with neonatal jaundice.

How is bilirubin eliminated from the newborn?

Bilirubin (a yellow substance) is naturally removed by the liver and then excreted in stool and urine. Bilirubin levels become high when bilirubin is made faster than it can be removed. Jaundice is common in newborns since two to three times more bilirubin is made than in adults.

What is IVIg used for in neonates?

Intravenous immune globulin (IVIG) may enhance immunity to neonatal bacterial pathogens by facilitating opsonophagocytosis. In early-onset neonatal sepsis, antibody has improved survival when used therapeutically in combination with antibiotics.

Which immunoglobulin is maximum in newborn?

There appeared to be a correlation of increased IgG with higher birth weight while lower birth weight infants had increased IgM. It is well recognised that the primary immunoglobulin (Ig) of the newborn is the maternal IgG as this is the only Ig to cross the placental barrier.

How do you apply IVIg?

Administer directly via the bottle provided by blood bank. Do not remove IVIg from the bottle and attempt to administer via a syringe driver. IVIg does not contain any antimicrobial preservative, therefore each bottle of IVIg must be administered within 6 hours from spiking the bottle.

Why is phototherapy needed for newborns with jaundice?

Phototherapy. Phototherapy is treatment with a special type of light (not sunlight). It’s sometimes used to treat newborn jaundice by making it easier for your baby’s liver to break down and remove the bilirubin from your baby’s blood. Phototherapy aims to expose your baby’s skin to as much light as possible.

When do you stop phototherapy for neonatal jaundice?

In some cases, phototherapy will only be needed for 24 hours or less, in some cases, it may be required for 5 to 7 days. The AAP Guidelines suggest that an infant readmitted for hyperbilirubinemia, with a level of 18 mg/dL or more, should have a level of 13 – 14 mg/dL in order to discontinue phototherapy.

Is IVIg safe for babies?

An IVIg infusion is a common and safe procedure. The IVIg your child will receive is supplied by the Australian Red Cross Blood Service.