Can you have dental work while on Xgeva?

Can you have dental work while on Xgeva?

Stop treatment with denosumab (Xgeva®) at least 3 weeks prior to any dental procedures. Prior to starting therapy, you should have a complete dental exam, cleaning, and removal of any teeth in poor health. Dentures should be checked for proper fit.

Can Xgeva make your teeth hurt?

Osteonecrosis of the jaw (ONJ) has been reported in patients receiving XGEVA®, manifesting as jaw pain, osteomyelitis, osteitis, bone erosion, tooth or periodontal infection, toothache, gingival ulceration, or gingival erosion.

Why do you need dental clearance for Xgeva?

Xgeva has been associated with osteonecrosis of the jaw. The risk of osteonecrosis of the jaw is greater in those who have received chemotherapy, radiation, or steroids. A routine oral examination should be completed by a dentist before Xgeva is started.

Does Xgeva cause jaw necrosis?

One uncommon but very serious side effect of Xgeva and Zometa (and other bisphosphonates) is jaw bone breakdown, called osteonecrosis of the jaw. Right now, there aren’t good treatment options when osteonecrosis of the jaw happens and the condition can be very disabling.

How long does Xgeva stay in your system?

If you don’t receive another dose of Xgeva, the amount of drug in your body will reduce by half after another 4 weeks. This continues until there is no more drug in your body. The drug stays in your body for about 140 days.

Does Xgeva suppress the immune system?

Denosumab can affect your immune system. You may be more likely to get a serious infection, such as a skin, ear, stomach/gut, or bladder infection.

What happens when you stop taking Xgeva?

Before you stop Xgeva treatment, it’s important to talk with your doctor. If you stop receiving the drug, it’s possible to develop hypercalcemia or bone fractures. To decrease your risk of these problems, your doctor may monitor your blood levels. (Too much calcium in your blood could harm your bones.)

When should I stop taking Xgeva?

Official Answer. Xgeva is meant to be taken long-term. However, Xgeva should be discontinued if you experience intolerable side effects or serious side effects such as osteonecrosis of the jaw or osteomyelitis, or if Xgeva appears to be ineffective for you.

How long can you stay on Xgeva?

Does Xgeva stop bone metastasis?

Xgeva (denosumab) is a preventive medicine developed by Amgen to check the spread of cancer to the bones. It was approved by US Food and Drug Administration (FDA) as the first and only rank ligand inhibitor for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumours in 2010.

How long does it take for osteonecrosis of the jaw to develop?

Osteonecrosis of the jaw is diagnosed when exposed, necrotic bone is present in the maxilla or mandible for at least 8 weeks.

Does Xgeva weaken your immune system?