Can a cell have multiple nuclei?
Multinucleate cells (multinucleated or polynuclear cells) are eukaryotic cells that have more than one nucleus per cell, i.e., multiple nuclei share one common cytoplasm.
How are cells with multiple nuclei produced?
Multinucleation is one mechanism adopted by cells to generate and sustain large cell sizes. Muscle cells are one of the largest cell types, which are formed by fusion of mononucleated myoblasts and contain up to several tens (invertebrates) to several hundred (vertebrates) nuclei.
What is the function of the nucleus Why are there so many nuclei per cell?
The nucleus is generally considered the control center of the cell because it stores all of the genetic instructions for manufacturing proteins. Interestingly, some cells in the body, such as muscle cells, contain more than one nucleus (Figure 3.20), which is known as multinucleated.
What purpose does having multiple nuclei serve for the muscle fiber?
Abstract. Many types of large cells have multiple nuclei. In skeletal muscle fibers, the nuclei are distributed along the cell to maximize their internuclear distances. This myonuclear positioning is crucial for cell function.
How could such multinucleated cells be explained?
Certain cell types normally have several nuclei per cell. How could such multinucleated cells be explained? The cell underwent repeated mitosis, but cytokinesis did not occur. In a diploid cell with 5 chromosome pairs (2n = 10), how many sister chromatids will be found in a nucleus at prophase of mitosis?
Why do skeletal muscles need multiple nuclei?
Because the muscle cell is so large, -from aprox insertion to origin-, it needs more myonuclei. In case of hypertrophy for instance the volume of the muscle cell can only enlarge when there are more nuclei. So it is multinucleated from functional and structural (very long) perspective.
What is the advantage of having multiple nuclei in a skeletal muscle cell?
The nuclei have a high concentration of myonuclei and sarcoplasmic reticulum involved in protein synthesis. The more nuclei, the more protein can be produced, which leads to a stronger skeletal muscle.
What cell has multiple nuclei?
Organisms that show multinucleate stage are fungi, e.g. coenocytic hyphae of Rhizopus, plasmodium of slime mould, skeletal muscle cells and osteoclasts in mammals are also multinucleate. Paramoecium (ciliated unicellular protozoan) contains one macronucleus and one or more micronucleus.
How do multinucleated cells function?
Multinucleated giant cells are important mediators of tissue remodeling and repair and are also responsible for removal or sequestration of foreign material, intracellular bacteria and non-phagocytosable pathogens, such as parasites and fungi.
What is the purpose of multinucleated?
Why are muscle cells multi nucleated?
During myogenesis in vitro, mononucleated myoblasts are induced to withdraw from the cell cycle by a decrease in growth factors, initiate muscle specific gene expression, and subsequently fuse with one another to form multinucleated myotubes.