How do you calculate AUC for vancomycin?

How do you calculate AUC for vancomycin?

The calculation determines the AUC24 to be 349 µg/mL x hr (outside the target range). If using the Sanford Guide vancomycin calculator, the daily dose range that will achieve the target AUC24 of 400-600 µg/mL x hr is reported.

What is the target AUC for vancomycin?

The new 2020 vancomycin guidelines promote the following pharmacodynamic targets: For adults and pediatrics, the desired target AUC:MIC ratio is 400-600. In neonates targeting a minimum AUC:MIC of 400 is desired.

How are Vanco clearances calculated?

Clearance

1. CLvanco (mL/min/kg) = ([CrCl × 0.0075] + 0.04)
2. Vd = 0.47 L/kg. Vd was estimated using an adjusted body weight (ABW).

How is vancomycin calculated?

Using the first-order elimination equation (Cp=Cp0∗e−kt), a true peak (Cmax) can be calculated using the time elapsed between the end of the vancomycin infusion and the first drug concentration (Cp0).

How do you calculate true vancomycin trough?

The value of the measured trough (MT) was then extrapolated to estimate the true trough (TT), using the equation: TT = MT × e−Kt. With this method of determining vancomycin K, it is important to use an uncorrected value of CrCl in mL/min, not one that has been corrected to a standard body surface area of 1.73 m2.

How is carboplatin AUC calculated?

Carboplatin Dose (mg) = Target area under the curve (AUC mg/mL/min) x (GFR* + 25) *GFR estimated by calculated creatinine clearance using Cockcroft-Gault Equation (see below).

What is AUC based dosing?

AUC-based vancomycin dosing derives the daily dose from ClVanco, MIC, and the desired AUC24/MIC, without consideration of the patient’s weight.

How do you calculate vancomycin trough?

To increase the therapeutic utility of an early vancomycin trough concentration, an estimate of the true trough can be determined by extrapolating the measured value using e−Kt, where K = CrCl × 0.00083 + 0.0044 and t is the time difference in hours.

What is vancomycin random level?

Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough levels is 5-15 mcg/mL. The reference range for vancomycin peak levels is 20-40 mcg/mL.