What type of cell is Bordetella pertussis?
Bordetella pertussis is a small (approximately 0.8 μm by 0.4 μm), rod-shaped, coccoid, or ovoid Gram-negative bacterium that is encapsulated and does not produce spores. It is a strict aerobe.
How does Bordetella pertussis affect cells?
Abstract. Bordetella pertussis, the causative agent of whopping cough, produces an adenylate cyclase toxin (CyaA) that plays a key role in the host colonization by targeting innate immune cells which express CD11b/CD18, the cellular receptor of CyaA.
Does Bordetella pertussis have a cell membrane?
Like other gram negative bacteria, it possesses an inner and outer membrane, with a thin peptidoglycan cell wall in between. This cell wall is attached to the outer membrane via lipoproteins. Like other gram negatives, the outer membrane of B.
What type of epithelial tissue does Bordetella pertussis impact?
pertussis infection damages ciliated epithelium, and the in vitro experiments suggest that tracheal cytotoxin may be responsible for the abnormalities observed in vivo.
Is Bordetella pertussis opportunistic pathogen?
Although other Bordetella species have been isolated from humans, they seem to be primarily opportunistic human pathogens. In the pre-vaccine era, pertussis was widespread and mainly affected young children (1–9 years old)7.
What type of pathogen causes pertussis?
Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.
How does pertussis toxin affect G protein Signalling?
PT catalyzes the ADP-ribosylation of the αi subunits of the heterotrimeric G protein. This prevents the G proteins from interacting with G protein-coupled receptors on the cell membrane, thus interfering with intracellular communication.
Is Bordetella pertussis an opportunistic pathogen?
What is the pathogenesis of Bordetella pertussis?
Pathogenesis. B. pertussis infection and disease occur after four important steps: (1) attachment, (2) evasion of host defenses, (3) local damage, and (4) systemic manifestations. Filamentous hemagglutinin (FHA) and fimbriae (FIM) are two major adhesins and virulence determinants forB.
How does pertussis enter the cell?
pertussis is able to enter those cells by a mechanism dependent on microtubule assembly, lipid raft integrity, and the activation of a tyrosine-kinase-mediated signaling.
Which toxin of Bordetella pertussis inhibits cells that line the trachea?
Of the virulence factors produced by Bordetella organisms, only tracheal cytotoxin induces paralysis and destruction of respiratory ciliated epithelium, the hallmark of pertussis disease. Tracheal cytotoxin is a fragment released from the peptidoglycan of the B. pertussis cell wall.