What is gammopathy?
A gammopathy is an abnormal increase in immunoglobulin synthesis. Gammopathies that are monoclonal usually signify malignancy such as multiple myeloma, Waldenström’s disease, heavy chains disease, or chronic lymphocytic leukemia.
What is monoclonal Plasmacytosis?
Multiple myeloma (MM) is characterized by abnormal proliferation of clonal plasma cells or monoclonal plasmacytosis, resulting in accumulation of clonal immunoglobulins. Monoclonal gammopathy of unknown significance (MGUS) is considered a premorbid stage for developing MM.
What is immunofixation test?
An immunofixation blood test, also known as protein electrophoresis, measures certain proteins in the blood. Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. There are two main types of proteins in the blood: albumin and globulin.
What is IgG MGUS?
IgG and IgA MGUS are defined by a M-protein less than 30 g/L, bone marrow (BM) plasma cell percentage less than 10%, and absence of signs or symptoms related to multiple myeloma (MM) (hypercalcemia, renal insufficiency, anemia, or bone lesions) or other lymphoproliferative malignancies such as Waldenström’s …
What is IgG Kappa?
The most common type of myeloma is IgG kappa. In IgG kappa myeloma, the myeloma cells produce an immunoglobulin made from two IgG heavy chains bound to two kappa light chains. About 15% of patients have light chain myeloma. In this type of myeloma, the myeloma cells secrete only light chain protein and no heavy chains.
What is a plasmacytoma?
Listen to pronunciation. (PLAZ-muh-sy-TOH-muh) A type of cancer that begins in plasma cells (white blood cells that produce antibodies). A plasmacytoma may turn into multiple myeloma.
What is Multi myeloma?
Multiple myeloma is a cancer of plasma cells. Normal plasma cells are found in the bone marrow and are an important part of the immune system. The immune system is made up of several types of cells that work together to fight infections and other diseases.
What does Paraproteinemia mean?
Paraproteinemia, also known as monoclonal gammopathy, is characterized by the presence of excessive amounts of paraproteins in the blood. Paraproteins are immunoglobulin proteins that are produced by a clone of plasma cells in the bone marrow. These proteins often cause damage to the kidneys.
https://www.youtube.com/watch?v=re8gAquXCNs