Which is the glucosidase inhibitors?

Which is the glucosidase inhibitors?

Alpha-glucosidase inhibitors are pills that treat type 2 diabetes. There are two medications in this group, or class, of drugs: acarbose (Precose) and miglitol (Glyset). They help keep the amount of glucose in your blood from going up too fast after you eat.

What is alpha glucosidase inhibitory activity?

Alpha-glucosidases are enzymes in the digestive tract that hydrolyze carbohydrates into glucose. One strategy that has been developed to treat type-2 diabetes is inhibition of the activity of alpha-glucosidases using synthetic drugs. However, these inhibitors are usually associated with gastrointestinal side effects.

What type of enzyme is glucosidase?

Glucosidase enzymes catalyze hydrolysis of starch to simple sugars. In humans, these enzymes aid digestion of dietary carbohydrates and starches to produce glucose for intestinal absorption, which in turn, leads to increase in blood glucose levels.

What does glucosidase do?

How do alpha glucosidase inhibitors work?

Alpha-glucosidase inhibitors work by competitive and reversible inhibition of these intestinal enzymes. They slow the digestion of carbohydrates and delay glucose absorption. This results in a smaller and slower rise in blood glucose levels following meals, and effectively throughout the day.

What inhibits alpha amylase?

Dietary phytic acid may have health-promoting properties. It can inhibit α-amylase, limit carbohydrate digestion, and lower blood glucose.

How is alpha amylase inhibited?

α-amylase enzyme was inhibited almost equally by both ethyl acetate extract (58.10 ± 1.60%) and acarbose (61.29 ± 2.62%) at especially 1 mg/mL concentration. In the light of the data obtained from the experiments, Achillea Biebersteinii was thought to have a blood glucose-lowering effect on postprandial hyperglycemia.

What is alpha amylase and alpha glucosidase?

Alpha glucosidase and alpha amylase are the important enzymes involved in the digestion of carbohydrates. Alpha Amylase is involved in the breakdown of long chain carbohydrates and alpha glucosidase breaks down starch and disaccharides to glucose.