What is STAMPEDE treatment?
STAMPEDE (Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy) is a large clinical trial that aims to assess new treatment approaches for people affected by high-risk prostate cancer.
What was the overall survival in abiraterone group?
The median overall survival was 14.8 months in the abiraterone acetate group and 10.9 months in the placebo group (Fig. 1A).
What is a stampede special?
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) is a clinical trial investigating treatments for high risk or terminal prostate cancer. Recruitment started in 2005 and ends in 2022 and in January 2020, over 10,000 participants have joined the trial.
What is ADT prostate?
Prostate cancer needs testosterone to grow. Reducing how much testosterone your body makes may slow the cancer’s growth or shrink the cancer temporarily. Testosterone is an androgen (male sex hormone), so this treatment is called androgen deprivation therapy (ADT).
What are the last stages of prostate cancer?
Signs and symptoms of stage 4 prostate cancer may include:
- Painful urination.
- Decreased force in the stream of urine.
- Blood in the semen.
- Bone pain.
- Swelling in the legs.
- Fatigue.
How long does a patient stay on Zytiga?
Many people with prostate cancer take Zytiga for 2–3 years, so the costs associated with their treatment can run into hundreds of thousands.
What is the life expectancy for metastatic bone cancer?
The authors note that most people live for 12–33 months after a diagnosis of metastatic cancer in the bones.
What is the Stampede trial?
Detailed Description: STAMPEDE (also known as MRC PR08) is a multi-arm multi-stage (MAMS) randomised controlled trial recruiting in the UK and Switzerland. It aims to evaluate multiple therapeutic strategies in the management of high-risk locally advanced and metastatic hormone-naïve prostate cancer.
What are the research arms in Stampede?
Summary of the research arms in STAMPEDE trial platform Summary of research treatment groups currently open to recruitment (June 2017) Metformin (Arm K): This anti-diabetic medication is proposed to have both anti-cancer effects and may help prevent the adverse metabolic effects of long-term ADT.
What is Stampede?
ABOUT STAMPEDE. Prostate cancer accounts for around one fifth of all male cancers. In the UK there are ~47,000 new cases each year and ~11,000 deaths. STAMPEDE aims to provide evidence as to what is the best way of treating men with newly diagnosed advanced prostate cancer. Since opening in 2005 over 10 000 participants have joined the trial.
What is prostate cancer and Stampede?
Prostate cancer accounts for around one fifth of all male cancers. In the UK there are ~47,000 new cases each year and ~11,000 deaths. STAMPEDE aims to provide evidence as to what is the best way of treating men with newly diagnosed advanced prostate cancer.