How is placental site trophoblastic tumor diagnosed?
Diagnosis is confirmed by dilatation and curettage (D and E) and hysterectomy but meticulous evaluation of metastasis is mandatory. Most cases are confined to the uterus but pelvic involvement, lung and other organ metastasis has been reported. Unlike other forms of GTD, the WHO prognostic score is of little help.
How is trophoblastic disease diagnosed?
Screening for Gestational Trophoblastic Disease CA-125 blood test: A blood test to determine if a tumor is present in your body. Serum tumor marker test: A blood test to measure the amount of beta human chorionic gonadotropin (β-hCG) in the body. This is a hormone that the body makes during pregnancy.
What is the most common site for an epithelioid trophoblastic tumor?
As squamous cell carcinoma and its associated intraepithelial lesions are the most common lesions of the uterine cervix, epithelioid trophoblastic tumor can pose a significant diagnostic challenge to routine surgical pathology practice.
What is intermediate trophoblast?
An intermediate trophoblast is a distinctive trophoblastic cell population from which four trophoblastic lesions are thought to arise: exaggerated placental site (EPS), placental site nodule (PSN), placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT).
Can GTD seen an ultrasound?
The diagnosis of a molar pregnancy, or hydatidiform mole is most commonly indicated by an ultrasound, a test which uses sound waves to show the contents of the uterus.
What causes placental tumor?
The cause of chorioangioma is unknown. The abnormal masses form in the chorionic tissue, the tissue on the fetal side of the placenta. Chorioangiomas occur in an estimated 1% of pregnancies. The tumors are seen more often in pregnancies where the fetus is female and in those involving multiples (twins, triplets, etc.).
What is placental site nodule?
Placental site nodule (PSN) is a rare benign lesion of the intermediate trophoblast which is thought to represent incomplete involution of the placental implantation site. PSN usually presents as menorrhagia, intermenstrual bleeding or an abnormal Pap smear.
Can a blood test detect molar pregnancy?
If your doctor suspects a molar pregnancy, he or she will order blood tests, including one to measure the level of human chorionic gonadotropin (HCG) — a pregnancy hormone — in your blood. He or she will also recommend an ultrasound.
Which of the following symptoms occur with a hydatidiform mole?
Abnormal growth of the uterus, either bigger or smaller than usual. Severe nausea and vomiting. Vaginal bleeding during the first 3 months of pregnancy.
What is placental site trophoblastic tumour (pstt)?
Placental site trophoblastic tumour (PSTT) is a very rare and unique form of gestational trophoblastic disease (GTD). This tumour represents a neoplastic transformation of intermediate trophoblastic cells that normally play a critical role in implantation. PSTT can occur after a normal pregnancy, ab … Placental site trophoblastic tumour
What is the abbreviation for gestational trophoblastic disease?
PSTT, a neoplasm of implantation site intermediate trophoblastic cells, is a rare form of gestational trophoblastic disease (GTD) < 3% of GTD cases Other previously used terms are atypical choriocarcinoma, syncytioma, chorioepitheliosis and trophoblastic pseudotumor
How do trophoblast cells invade the myometrium?
Tumor cells often aggregate into confluent sheets; however, at the periphery the trophoblast cells invade singly or in cords and nests, characteristically infiltrating the myometrium by separating individual muscle fibers and groups of fibers