What is a co-processed excipients?
A co-processed excipient is any combination of two or more excipients obtained by physical co-processing that does not lead to the formation of covalent bonds. Co-processed excipients have functionalities that cannot be achieved through sample blending.
How do you make co-processed excipients?
The co-processed excipients were prepared by granulation technique. The blends containing the drug and co-processed excipients were formulated into a tablet by direct compression method. The direct compression method is most widely accepted process for hydrophobic drugs to be formulated into tablet dosage forms.
What are diluents excipients?
Diluents act as fillers in pharmaceutical tablets to increase weight and improve content uniformity. Natural diluents include starches, hydrolyzed starches, and partially pregelatinized starches.
What is an excipient ingredient?
An excipient is a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term stabilization, bulking up solid formulations that contain potent active ingredients in small amounts (thus often referred to as “bulking agents”, “fillers”, or “diluents”), or to confer a …
What are the uses of pharmaceutical excipients?
Pharmaceutical excipients are substances that are included in a pharmaceutical dosage form not for their direct therapeutic action, but to aid the manufacturing process, to protect, support or enhance stability, or for bioavailability or patient acceptability.
Is water an excipient?
Water is one of the major utilities used by the pharmaceutical industry. It may be present as an excipient or used for reconstitution of products, during synthesis, during production of the finished product or as a cleaning agent for rinsing vessels, equipment, primary packaging materials, etc.
What is required from an excipient?
What are co-processed excipients and how are they prepared?
• Co-processed excipients are prepared by incorporation of one excipient into the particle structure of another excipient in order to • Mask undesired properties of individual materials and • Retain or improve desired properties of individual materials resulting in performance enhancement.
What are the different types of excipients?
Single entity excipients. Mixtures or blends of multiple excipients. Novel excipients or new chemical entities. Co -processed excipients. group of excipients to be co-processed.
What is the difference between standard and mixed excipients?
Standard Excipients nor co-processed excipients. They may contain other components including concomitant components, residual processing aids and/or additives. 2. Mixed Excipients the components is not chemically changed,.
How does the novel excipient compare with the individual components?
The novel excipient was evaluated for its direct compression and enhanced disintegrant properties and the result compared with the properties of the individual components.