What is targeted resequencing?
Targeted resequencing is a method that aims to identify causative mutations within discrete genomic loci in populations by isolating and sequencing genomic regions of interest from a sample library. It is one of the fastest growing applications for next-generation sequencing technologies.
What is targeted variant analysis?
Targeted genetic analysis is used to determine if a specific familial variant is present. Testing is only available for genes tested by Next Generation sequencing at Versiti Wisconsin, Inc., a sample from an affected relative must be provided a copy of the family member’s lab report for the variant being tested.
How does targeted sequencing work?
Targeted sequencing uses deep sequencing to detect known and novel variants within your region of interest. This method generally requires less sample input and produces a smaller amount of data than WGS, making analyses more manageable.
What is targeted gene testing?
Introduction to Targeted Gene Sequencing Targeted gene sequencing panels are useful tools for analyzing specific mutations in a given sample. Focused panels contain a select set of genes or gene regions that have known or suspected associations with the disease or phenotype under study.
What are targeted panels?
Targeted gene sequencing panels are useful tools for analyzing specific mutations in a given sample. Focused panels contain a select set of genes or gene regions that have known or suspected associations with the disease or phenotype under study.
What is genome resequencing?
Resequencing the genome of many individuals for which there is a reference genome allows investigation of the relationship between sequence variation and normal or disease phenotypes.
What is gene resequencing?
Sequencing a new example of a species for which a reference genome already exists is known as resequencing. Discovering what makes the new bacterial genome different from the reference is much easier than assembling a new reference genome.
What are the advantages of targeted resequencing?
The deep coverage offered by targeted resequencing allows for higher sensitivity to call variants in rare tumor subclones accurately. Learn more about targeted cancer sequencing. Targeted sequencing is a relatively inexpensive technique that interrogates known disease-causing genes.
What is targeted cancer sequencing?
Targeted sequencing studies focus on a select set of genes or gene regions that have known associations with cancer. The deep coverage offered by targeted resequencing allows for higher sensitivity to call variants in rare tumor subclones accurately. Learn more about targeted cancer sequencing.
What is the difference between whole-genome and targeted sequencing?
Compared to broader approaches, such as whole-genome sequencing, targeted sequencing is a more cost-effective method for investigating areas of interest.
What are targeted approaches to next-generation sequencing?
Targeted approaches using next-generation sequencing (NGS) allow researchers to focus time, expenses, and data analysis on specific areas of interest. Such targeted analysis can include the exome (the protein-coding portion of the genome), specific genes of interest (custom content), targets within genes, or mitochondrial DNA.