How is argatroban administered?
Initial Dosage: Initiate an infusion of Argatroban Injection at 25 mcg/kg/min and administer a bolus of 350 mcg/kg via a large bore intravenous line over 3 to 5 minutes (see Table 2). Check an activated clotting time (ACT) 5 to 10 minutes after the bolus dose is completed.
What is the indication for argatroban?
Argatroban Injection is indicated for prophylaxis or treatment of thrombosis in adult patients with heparin-induced thrombocytopenia (HIT).
How is Dabigatran administered?
When dabigatran is used to prevent a DVT or PE after hip replacement surgery, it is usually taken 1 to 4 hours after surgery, and then once a day for another 28 to 35 days. Dabigatran capsules may be taken with or without food. Take dabigatran capsules with food if the medication upsets your stomach.
How does argatroban affect act?
Monitoring of argatroban anticogulation An infusion of 2 μg/kg/min argatroban is expected to increase aPTT 1.5-fold, whereas an infusion of 10 μg/kg/min can prolong a PTT up to 3-fold. In the PCI setting, the ACT is prolonged to 275–450 sec under 15–25 μg/kg/min argatroban (Yeh and Jang 2006).
When is dabigatran prescribed?
About dabigatran It’s used to treat people who have had a health problem caused by a blood clot, such as: a stroke. a heart attack. a blood clot in the leg (deep vein thrombosis, or DVT)
What is dabigatran used to treat?
Dabigatran is used to decrease the risk of stroke and blood clots in patients with a serious heart rhythm problem called nonvalvular atrial fibrillation.
What is argatroban used to treat?
Last updated on Nov 1, 2018. Argatroban in sodium chloride injection is indicated for prophylaxis or treatment of thrombosis in adult patients with heparin-induced thrombocytopenia (HIT).
How do you prepare argatroban for intravenous administration?
Preparation for Intravenous Administration. Argatroban Injection should be diluted in 0.9% Sodium Chloride Injection, 5% Dextrose Injection, or Lactated Ringer’s Injection to a final concentration of 1 mg/mL. The contents of each 2.5-mL vial should be diluted 100-fold by mixing with 250 mL of diluent.
How many mg of argatroban are in a vial?
Argatroban in Sodium Chloride Injection is indicated as an anticoagulant in adult patients with or at risk for HIT undergoing percutaneous coronary intervention (PCI). Each 50 mL glass vial contains 50 mg of Argatroban (1 mg/mL); and, as supplied, is ready for intravenous infusion.
What is the initial dose of argatroban in sodium chloride?
The recommended initial dose of Argatroban in sodium chloride injection for adult patients without hepatic impairment is 2 mcg/kg/min, administered as a continuous infusion (see Table 1). Table 1.