What is Canrenone used for?
Canrenone is an antimineralocorticoid and active metabolite of spironolactone used in the treatment of primary hyperaldosteronism and edematous states caused by secondary hyperaldosteronism (e.g. heart failure). Canrenone has been used in trials studying the diagnostic of Heart Failure.
What type of diuretic is eplerenone?
Synopsis: Eplerenone, a potassium-sparing diuretic similar to spironolactone, selectively blocks aldosterone to lower blood pressure. However, its safety profile is improved over spironolactone because of reduced progesterone and androgen-receptor effects.
Which of the following diuretic is metabolized into active substance Canrenone?
Canrenone is a diuretic metabolite of spironolactone, the prototypic aldosterone antagonist diuretic. In vivo, spironolactone is metabolized to canrenone, which prolongs the biological effectiveness of spironolactone.
Why is Canrenone banned?
Canrenone is a derivative of spironolactone that is also prohibited. Both drugs are specific pharmacologic antagonists of aldosterone (a hormone that affects the body’s ability to regulate blood pressure), that cause increased amounts of sodium and water to be excreted, while potassium loss is minimized.
What is the primary target for thiazide diuretics?
The primary target of hydrochlorothiazide (and other thiazide/thiazide-like diuretics) is the sodium-chloride symporter (SLC12A3, NCC) on the apical membrane of the renal distal tubule. Hydrochlorothiazide is transported from the blood to its site of action by the renal proximal tubule organic acid secretory pathway.
What is eplerenone made of?
Eplerenone is chemically described as Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3- oxo-, γ-lactone, methyl ester, (7α,11α,17α)-. Its empirical formula is C24H30O6 and it has a molecular weight of 414.50.
Which is a potassium-sparing diuretics?
Examples of potassium-sparing diuretics include:
- Amiloride (Midamor)
- Eplerenone (Inspra)
- Spironolactone (Aldactone, Carospir)
- Triamterene (Dyrenium)
Is spironolactone hard on your kidneys?
3) Diuretics Diuretics, or water pills, are used to treat conditions like high blood pressure, glaucoma, and edema, but as with all medications, they come with some risks. Popular diuretics include hydrochlorothiazide, furosemide, and spironolactone. They are associated with a risk for acute kidney injury.