Does apoptosis trigger differentiation?
Apoptosis is essential to prevent oncogenic transformation by triggering self-destruction of harmful cells, including those unable to differentiate. However, the mechanisms linking impaired cell differentiation and apoptosis during development and disease are not well understood.
How does activation induced cell death work?
Activation-induced cell death (AICD) is the process by which cells undergo apoptosis in a controlled manner through the interaction of a death factor and its receptor.
How is apoptosis involved in T cell differentiation Why is this important?
ABSTRACT. Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses.
What is cell differentiation and apoptosis?
Apoptosis and differentiation are physiological processes that share many common features, for instance, chromatin condensation and the activation of caspases are frequently observed. It is, therefore, not surprising that many recent reports imply HSPs in the differentiation process.
Why does cell death occur during development?
Physiological mechanisms of cell death are used by multicellular organisms for development and morphogenesis, to control cell number, and as a defensive strategy to remove infected, mutated, or damaged cells.
What is released by the activated T cells quizlet?
Signal 1 stimulates expression of CD40 ligand (CD40L) on T cells! what happens to activated T cells? Activated T cells secrete interleukin-2 (IL-2) and develop the high affinity IL-2 receptor (IL-2R)!
What morphological features distinguish programmed cell death and necrotic cell death?
Our results indicate that morphological criteria (apoptotic cell rounding and shrinkage, and appearance of membrane bubbles in early necrosis) allow to distinguish these cell death mechanisms, and also show that, independently of the damaging agents, the necrotic process occurs in a characteristic sequence (coalescence …
Why is apoptosis called programmed cell death?
If cells are no longer needed, they commit suicide by activating an intracellular death program. This process is therefore called programmed cell death, although it is more commonly called apoptosis (from a Greek word meaning “falling off,” as leaves from a tree).
Why is programmed cell death important for proper development of a fetus?
Programmed cell death plays an important role in the processes of gamete maturation as well as in embryo development, contributing to the appropriate formation of various organs and structures. Apoptosis is one of the mechanisms of action of various cytotoxic agents and teratogens.
How do apoptotic cells induce compensatory cell proliferation?
Ryoo HD, et al. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev. Cell. 2004;7:491–501.
What is the role of caspase inhibition during apoptosis in Drosophila?
Ryoo HD, et al. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev. Cell. 2004;7:491–501. [PubMed] [Google Scholar] 10. Perez-Garijo A, et al. Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila. Development.
Is c-Myc a necessary component of activation-induced apoptosis in T cell hybridomas?
Antisense oligonucleotides corresponding to c-myc block the constitutive expression of c-Myc protein in T cell hybridomas and interfere with all aspects of activation-induced apoptosis without affecting lymphokine production in these cells. These data indicate that c-myc expression is a necessary component of activation-induced apoptosis.
What are the two forms of apoptosis-induced compensatory proliferation?
Therefore, there are two distinct forms of apoptosis-induced compensatory proliferation; one dependent on the initiator caspase Dronc, and the other dependent on the effector caspases DrICE and Dcp-1 (Figure 4b). Under what conditions are these two forms of compensatory proliferation used?