Does mucin mean cancer?

Does mucin mean cancer?

Mucinous carcinoma is a type of invasive cancer in which mucin — the main component of mucus — surrounds the cancer cells. While this form of cancer can develop in any part of the body that produces mucin, most cases occur in the breast. Colloid carcinoma is another name for mucinous carcinoma of the breast.

What is the survival rate of mucinous adenocarcinoma?

In the subjects who underwent curative resection, the 5-year survival rate for those with mucinous adenocarcinoma was significantly worse than for those with nonmucinous adenocarcinoma (54 vs 73.3 percent; P = 0.0020).

How does mucin cause cancer?

Mucinous carcinoma is an invasive type of cancer that begins in an internal organ that produces mucin, the primary ingredient of mucus. The abnormal cells inside this type of tumor are floating in the mucin, and the mucin becomes a part of the tumor.

What causes mucinous ovarian cancer?

The only clinical risk factor associated with mucinous ovarian cancer is tobacco smoking. Mucinous tumors are characteristically diagnosed in patients who are younger than patients in whom other epithelial ovarian cancers are diagnosed.

Is mucinous ovarian cancer curable?

Objectives: Patients with mucinous ovarian carcinoma (MOC) generally have a favorable prognosis, although in advanced stage, prognosis is significantly worse compared to patients with serous ovarian carcinomas (SOCs). This might be due to the difficulties in distinguishing MOC from metastatic tumors.

Is there a link between mucin production and cancer?

Deregulation of mucin production has therefore provided an important link between inflammation and cancer. Moreover, carcinoma cells derived from epithelia, including those of the breast, prostate, lung and pancreas, commonly overexpress transmembrane mucins to exploit their role in promoting growth and survival.

What is the role of MUC4 mucin in pancreatic cancer?

Chaturvedi P, et al. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res. 2008;68:2065–2070. [PMC free article][PubMed] [Google Scholar] 35. Gumbiner BM. Regulation of cadherin-mediated adhesion in morphogenesis. Nature Rev Mol Cell Biol. 2005;6:622–634. [PubMed] [Google Scholar] 36.

What is Mucinous carcinoma?

Mucinous carcinoma is either pure or mixed. “Pure” means that these are the only cancer cells present. “Mixed” means the mucinous carcinoma cells are mixed with other cancer types. Mucinous carcinoma may also be called colloid carcinoma. It’s a subtype of invasive ductal carcinoma that is a more common form of breast cancer.

What is the recombinant C-terminus of human MUC2 mucin?

The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem J. 2003;372:335–345. [PMC free article][PubMed] [Google Scholar] 8. Velcich A, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002;295:1726–1729.

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