What is a high IGF-1?

What is a high IGF-1?

Higher than normal levels of IGF-1 may mean gigantism in children or acromegaly in adults. Gigantism and acromegaly are most often caused by a tumor in the pituitary gland, a small organ in the base of the brain that controls many functions, including growth.

How do I know if my IGF-1 is low?

In adults, abnormally low levels of GH and/or IGF-1 may cause subtle, nonspecific symptoms such as:

1. Decreased bone density.
2. Fatigue.
3. Adverse lipid changes.
4. Reduced exercise tolerance.
5. Depression.
6. Thinning, dry skin.

What does a low IGF-1 level mean?

Low Circulating Levels of IGF-1 in Healthy Adults Are Associated With Reduced β-Cell Function, Increased Intramyocellular Lipid, and Enhanced Fat Utilization During Fasting.

What is IGF Z-score?

The Z score is the approximate number of standard deviations a given result is above (positive score) or below (negative score) the age- and sex-adjusted population median. Z scores are calculated using the measured IGF-1 concentration and parameters provided by the assay manufacturer.

How do you increase IGF-1?

Which foods increase IGF-1 levels?

1. protein derived from milk, fish and poultry, but not red meat (Giovannucci and coworkers, 2003)
2. protein derived from red meat, fish, seafood and zinc (Larsson and coworkers, 2005)
3. dietary fat, saturated fat and protein, but not carbohydrate (Heald and coworkers, 2003)

Should IGF-1 be high or low?

Low IGF-1 is considered by most to be between 84–100 µ/l and numerous studies recommend that raising IGF-1 to high normal range reverses Chronic Medical Diseases (CMD), improves bone mineral density (BMD), and fibromyalgia.

Is IGF-1 a growth hormone?

Conclusion: IGF-1 is an important growth hormone, mediating the protein anabolic and linear growth promoting effect of pituitary GH. It has a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimised by the synergistic action with GH.