Can PPI cause hypomagnesemia?

Can PPI cause hypomagnesemia?

Hypomagnesemia has recently been recognized as a side effect of PPIs. Low magnesium levels may cause symptoms from several systems, some of which being potentially serious, such as tetany, seizures and arrhythmias.

Do PPI interfere with magnesium?

PPIs may decrease intestinal magnesium (Mg) absorption by interfering with both active [transient receptor potential melastatin (TRPM) protein channels] and passive (paracellular pores) absorption [6, 7].

Why do PPIs cause low magnesium?

Proton pump inhibitors (PPIs) promote hypomagnesemia through loss of active Mg2+ absorption via transient receptor potential melastatin-6 and -7 (TRPM6/7). Danziger et al. confirm the association of PPIs with hypomagnesemia in patients hospitalized at a tertiary medical center.

Does omeprazole interfere with magnesium?

Long-term use of proton-pump inhibitors such as esomeprazole (Nexium), lansoprazole (Prevacid 24HR and generics), and omeprazole (Prilosec OTC and generics) can cause low magnesium levels, according to an announcement today from the Food and Drug Administration.

Do all PPIs cause magnesium deficiency?

[3-2-2011] The U.S. Food and Drug Administration (FDA) is informing the public that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year).

Can PPI cause hyponatremia?

Small observational studies and case reports have indicated that proton pump inhibitors (PPIs) may cause hyponatremia. Whether there is a difference between the individual PPIs is yet unknown. Since PPIs are one of the most commonly prescribed groups of drugs, even a rare adverse reaction may have large implications.

Can GERD cause low magnesium?

WASHINGTON — Use of proton pump inhibitors (PPIs) regularly for a year or longer may lead to low levels of circulating magnesium, which may increase the risk of leg spasms, arrhythmias, and seizures, according to an FDA warning.

Can pantoprazole cause hypomagnesemia?

Conclusions: All PPIs were associated with hypomagnesemia, with esomeprazole having the lowest risk and pantoprazole having the highest risk. The risk of PPI-associated hypomagnesemia was higher in males and the elderly population. Hypocalcemia and hypokalemia commonly coexisted with PPI-associated hypomagnesemia.

Is magnesium FDA approved?

FDA Announces Qualified Health Claim for Magnesium and Reduced Risk of High Blood Pressure | FDA.

Why do PPIs cause low sodium?

The underlying pathophysiological mechanism of PPI-induced hyponatremia is not clearly understood [8]. It is probably due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Salt-losing nephropathy caused by acute interstitial nephritis may play a role as well.