What happens when COX-1 and 2 inhibited?

What happens when COX-1 and 2 inhibited?

COX-2 inhibitors are NSAIDs that selectively block the COX-2 enzyme and not the COX-1 enzyme. Blocking this enzyme impedes the production of prostaglandins by the COX-2 which is more often the cause the pain and swelling of inflammation and other painful conditions.

Where are COX-1 and COX-2 located?

COX-1 was found in blood vessels, interstitial cells, smooth muscle cells, platelets and mesothelial cells. In contrast, COX-2 was found predominantly in the parenchymal cells of many tissues, with few exceptions, for example the heart.

What is COX-1 responsible for?

COX-1 appears to be responsible for the production of prostaglandins (PG) that are important for homeostatic functions, such as maintaining the integrity of the gastric mucosa, mediating normal platelet function, and regulating renal blood flow.

What are COX-1 inhibitors?

Cox-1 inhibitor: An agent that inhibits the action of the enzyme cox-1 (cyclooxygenase-1). The common anti-inflammatory drugs such as aspirin, ibuprofen, and naproxen block the action of both cox-1 and cox-2.

Which drug is a COX-1 inhibitor?

COX-1 inhibitors such as acetylsalicylic acid (ASA) inactivate platelet COX-1, a pivotal enzyme in TXA2 and prostacyclin synthesis, important for platelet secretion and aggregation.

What are COX-2 inhibitors?

Cox-2 inhibitors. Other names: Cyclo-oxygenase-2 inhibitors. Cyclooxygenase-2 (COX-2) inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that specifically blocks COX-2 enzymes. Nonsteroidal anti-inflammatory agents (usually abbreviated to NSAIDs) are a group of medicines that relieve pain and fever and reduce inflammation.

What is the function of COX-1 enzymes in nonsteroidal anti-inflammatory drugs?

Nonsteroidal anti-inflammatory agents (usually abbreviated to NSAIDs) are a group of medicines that relieve pain and fever and reduce inflammation. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels…

What is the difference between Cox 1 and Cox 2 NSAIDs?

NSAIDS are COX 1 inhibitor and enzyme inhibition causes decrease of fever, pain and increase occurrence of mucosal ulcers. Similarly, inhibition of COX 2 enzyme causes decreased fever and pain but symptoms of ulcers are not observed. COX 2 NSAIDs inhibitors decrease secretion of prostaglandin only in inflammatory tissue and not mucosal membrane.

What is the difference between COX1 and COX2 enzymes?

There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing…