What is normal range for fecal elastase?

What is normal range for fecal elastase?

Provides information to assist in interpretation of the test results. Pancreatic elastase concentrations above 200 mcg/g are normal and are not indicative of exocrine pancreatic insufficiency. Pancreatic elastase concentrations from 100-200 mcg/g are suggestive for moderate exocrine pancreatic insufficiency.

Is pancreatic elastase of 500 normal?

Although research typically indicates levels of PE1 less than 200 mcg/g to be consistent with normal pancreatic exocrine function, healthy individuals produce on average 500 mcg/g of PE1.

Can stool elastase be too high?

A level that’s too high is a sign of a problem. Fecal elastase test. You’ll give your doctor a solid stool sample.

What does it mean to have abnormal elastase in stool?

Stool pancreatic elastase is a marker used to define exocrine pancreatic function, with low levels indicating the presence of pancreatic insufficiency which can be the result of a number of different ailments such as chronic pancreatitis, pancreatic cancer, cystic fibrosis, diabetes and Crohn’s disease1.

How do you interpret faecal elastase?

Interpretation: Faecal elastase is reduced in pancreatic exocrine failure. Malabsorption is not usually obvious until > 95% of the pancreas has been destroyed. Values of 100-200 µg/g indicate moderate, and < 100 µg/g severe, pancreatic insufficiency.

Is pancreatic elastase 400 normal?

Intermediate pancreatic function is diagnosed at 200–400 ug/g and normal pancreatic function is anywhere above 400 ug/g.

Can a fecal elastase test be wrong?

In patients with low pre-test probability of EPI (5%), the fecal elastase-1 assay would have a false-negative rate of 1.1% and a false-positive rate of 11%, indicating a high yield in ruling out EPI but not in detection of EPI.

Can fecal elastase fluctuate?

Pancreatic elastase 1 in stool: variations within one stool passage and individual changes from day to day.

What does raised faecal elastase mean?

It is often seen in conditions such as chronic pancreatitis and sometimes pancreatic cancer. In children, it is most frequently associated with cystic fibrosis (CF) or Shwachman-Diamond syndrome (SDS).

What does a faecal elastase test for?

The pancreatic elastase test, often referred to as “fecal elastase,” is a helpful tool for identifying exocrine pancreatic insufficiency in people who have gastrointestinal symptoms, such as abdominal pain, diarrhea, and unexplained weight loss.

When is fecal elastase checked?

An elastase test may be ordered when a person has signs and symptoms of pancreatic insufficiency, such as:

1. Abdominal cramps and bloating.
2. Foul-smelling, bulky, greasy stools.
3. In children, an inability to gain weight, delayed growth.
4. Malabsorption.
5. Malnutrition.
6. Vitamin deficiencies.
7. Weight loss.

How is low pancreatic elastase treated?

The most effective treatment for PEI is pancreatic enzyme replacement therapy (PERT), which involves taking a medication called pancrelipase (Cotazym®, Creon®, Pancrease® MT) to provide the body with enzymes that break down fats and proteins.